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This structural variation confers upon Tocotrienols potent neuroprotective, antioxidant, anti-cancer, and cholesterol-lowering effects, which have been demonstrated in numerous preclinical and clinical studies (Sen et al., 2006, Sen, Khanna, & Roy, 2007, Shrum et al., 2023, Talib et al., 2024)

Tocher DR, Betancor MB, Sprague M, Olsen RE, Napier JA (2019) Omega-3 long-chain polyunsaturated fatty acids, EPA and DHA: Bridging the gap between supply and demand

For example, a single-cell omics study revealed that cells of the same origin can take on different trajectories during senescence initiation and ultimately transition into distinct clusters

Immune dysfunction takes responsible to various kinds of liver diseases, including DILI, fatty liver disease, autoimmune liver disease, etc.[34, 35]

Recently, increasing attention has been focused on the application of metal complexes to catalyze the transformation of biological essential biomolecules into (cytotoxic) products or products that ultimately lead to cell death

Small human studies are now starting: one trial in MS is testing oral sodium butyrates effect on MRI and immune markers [263]