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*Correspondence: Zhiquan Yang, [email protected] This article was submitted to Cellular Neuropathology, a section of the journal Frontiers in Cellular Neuroscience Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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The net effect is an analog that is still recognized well by the IGF-1 receptor but poorly by the binding proteins precisely the profile that makes it valuable as a persistent, free-ligand research tool