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A short note before we get into specifics

Figure 5 With reference to the American Joint Committee on Cancer (AJCC), the stages of cancer can be classified into what is called the TNM system, where T is the breast tumour size, N is the extent of breast tumour spread to nearby lymph nodes, and M represents the extent of breast tumour metastasis to other parts or organs of the body ( Table 3 ) (144147)