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The primary pathways for clearing L-OOHs in ferroptosis are the cystine/glutamate antiporter system-glutathione-glutathione peroxidase 4 axis (System Xc-/GSH/GPX4 axis), the ferroptosis suppressor protein 1-coenzyme Q10-nicotinamide adenine dinucleotide phosphate axis (FSP1/CoQ10/NADPH axis), and the GTP cyclohydrolase 1-tetrahydrobiopterin-dihydrofolate reductase axis (GCH1/BH4/DHFR axis) (Figure 1C)

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Zaleplon, a widely used non-benzodiazepine hypnotic, exerts sedative effects by selectively binding to the -1, -2, and -2 subunits of the GABA_A receptors in the CNS, enhancing GABAergic inhibition and thereby lowering neuronal excitability to induce sleep

Executive functions Executive functions refer to several higher-order cognitive processes, such as reasoning, planning, strategic thinking, problem solving, and multitasking (101, 130, 131)

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also demonstrated that Asn levels are increased in activated CD8 + T cells and bind to the SRC family tyrosine kinase LCK, assisting in the phosphorylation of LCK at Tyr394 and 505, enhancing LCK activity and T-cell receptor signaling