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Additionally, cell division cycle 6 (CDC6) and minichromosome maintenance 10 replication initiation factor (MCM10), which are associated with the DNA replication pathway, were also downregulated in treated SPF mice [253]

873 The expression of ACSL4 and 4-HNE increase in the cartilage of OA patients and OA mice, while metformin increases p-AMPK and p-ACC levels in IL-1-treated chondrocytes, reverses ACSL4 and 4-HNE positive chondrocytes and OA lesions, and improves the ferroptosis sensitivity of chondrocytes through the AMPK/ACC pathway