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Reduced glutathione (GSH) is the active, bioavailable form your body uses for antioxidant defence and detoxification

14 Natives or long-term high-altitude sojourners, who are chronically exposed to altitude hypoxia, may develop several altitude-related illnesses, including polycythemia, systemic hypertension, pulmonary hypertension, congenital heart disease, thromboembolic disease, lung disease, mental deterioration, as well as pregnancy and neonatal problems

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Welch et al

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Although stress is also a factor which may influence insulin resistance, no doctor treating individuals with diabetes would consider that those needing higher doses of insulin are mentally unstable, making up their disease, or suffering from the placebo effect