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S-adenosylmethionine (SAM), a product of one carbon metabolism, serves as the universal methyl donor for methyltransferase enzymes, which catalyze transfer of the sulfonium methyl group of SAM to nucleophilic acceptors such as the -amino group of lysine residues on proteins 13 , the 5-position of cytosine in DNA 46 and RNA 7,8 , or the ethanolamine head group of phosphatidylethanolamine in lipids 9,10

Elnaggar YSR, Etman SM, Abdelmonsif DA, Abdallah OY (2015) Intranasal piperine-loaded chitosan nanoparticles as brain-targeted therapy in Alzheimers disease: optimization, biological efficacy, and potential toxicity

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Aims: To review evidence on the neurological and psychiatric side effects of antibiotics and evaluate potential neuroprotective strategies like N-acetylcysteine (NAC) and ketone bodies