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In a DKD rat model, M1 markers like CD86, TNF-, and inducible nitric oxide synthase (iNOS) were elevated, while Sirt6 expression was significantly reduced, alongside M2 markers such as CD206, IL-4, and IL-10 [REF (119)]

Specifically, TET2 knockdown in myeloid cells has been demonstrated to slow the growth of tumors and improve the infiltration and function of CD8 + T cells in the TME [101]

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Such changes in turn leads to weakened SCN output, impaired photic entrainment, and loss of temporal coherence across organ systems