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This results in neurological decline, anemia, and immune dysfunction unless supplementation is provided

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Pharmacogenet Genomics 26:243247 Xu H, Robinson GW, Huang J, Lim JY, Zhang H, Bass JK, Broniscer A, Chintagumpala M, Bartels U, Gururangan S, Hassall T, Fisher M, Cohn R, Yamashita T, Teitz T, Zuo J, Onar-Thomas A, Gajjar A, Stewart CF, Yang JJ (2015) Common variants in ACYP2 influence susceptibility to cisplatin-induced hearing loss

Rest helps initially but extended inactivity leads to muscle weakness and stiffness