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Using nuclear magnetic resonance (NMR)-based metabolomics to obtain serum metabolic profiles of doxycycline-treated ( n = 60) and standard therapy of COPD patients ( n = 40), doxycycline (100 mg) significantly increased the values of FEV1/forced vital capacity (FVC) and improved the COPD assessment test (CAT) scores after 3 months treatment

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To access a fraction of that library in a proof-of-concept study, a 96-well assay containing ()- t -ES, Cp1B and Cp1D, eight proteinogenic amino acids (l-Ile, l-Leu, l-Val, l-Met, l-Phe, l-Trp and l-Tyr, with l-His as a negative control) and 12 amine donors including additionally tested amines such as spermidine ( b42 ), 4-(2-aminoethyl)-pyridine ( b43 ) and tryptamine ( b44 ) were performed

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To illustrate the success of the application and the way of application efficacy, it may be instructive to mention the noted effect in the recovery of the transected sciatic nerve injury (providing the efficacy of the once intraperitoneal, intragastric application much like the application into the tube with inserted nerve stumps) (Gjurasin et al., 2010)

Therefore, inflammatory responses after drug administration were measured by quantification of cytokines in sampled vascular supernatants (Fig