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10.1016/j.nbd.2007.11.011 [DOI] [PMC free article] [PubMed] [Google Scholar] Chang J

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Subsequently, Nuclear Factor Erythroid 2-related Factor 2 (NRF2) was identified as a transcription factor involved in regulating gene expression at these ARE sequences (Itoh et al., 1997

Rather than overriding pain signals, this model works to identify and address the root causes of chronic pain such as chronic inflammation, tissue injury, biomechanical imbalance, nutrient depletion, metabolic dysfunction, gut-immune disruption, or nervous system sensitization