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Survival curve of C57BL/6 mice after 90% hepatectomy ( n = 6 and 14

In our study, RNA-seq of RTECs with REST knockdown under HR, primary RTECs of mice with Rest knockout, histological examination of Rest RTKO mouse kidneys, and TEM observations collectively demonstrated that ferroptosis was one of the key regulatory pathways through which REST contributed to AKI-to-CKD transition

However, when GPX4 mito was down-regulated with GPX3 knockdown, the expression level of DHODH in mitochondria increased, whereas GPX3 overexpression did not affect it

Metabolites 2024, 14(12)

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Within the glial population, oxysterols emerge as potent regulators of neuroinflammation and myelin dynamics