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Experimental evidence indicates that targeted BCAA or leucine supplementation can support mitochondrial function and aspects of muscle bioenergetics in aging models, although effects depend on dose, duration, and context (2426)

doi: 10.1016/j.envint.2013.12.007 36 AyyavooA

Urbina PhD 2 , Flor Lpez MSc 2 , Frank Hernndez Rosales PhD 1 1 Ozone Research Center, National Center for Scientific Research

Although previous studies identified that RIDD functions mainly in the clearance of ER-bound transcripts as a mechanism to reduce the load of ER client proteins during ER stress, more recent studies have also revealed an active role of RIDD in determining cell fate 61