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Aptamers have different advantages over antibodies, including much smaller size (making them more appropriate to penetrate solid tumors), less immunogenicity (reducing resistance to treatment), the capability to manipulate their length and physicochemical properties (making them possible to change the half-life, pH sensitivity, flexibility, and conjugation capacity), fast and simple production procedure, negligible inter-batch variation, and better temperature resistance [210,211,212,213,214]