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In the VITACOG trial, high-dose B vitamins in older adults with mild cognitive impairment and elevated homocysteine reduced atrophy in the gray matter regions most vulnerable to Alzheimers disease, with the placebo group losing about 3.7 percent and the treatment group about 0.5 percent over two years

Importantly, treatment with marmelosin at both doses demonstrated a significant attenuation of these pathological changes, encompassing a reduction in interstitial inflammation, amelioration of pancreatic follicle cell swelling and necrosis, and a notable improvement in the organization of islet architecture (Figure 10AD)

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In the future, disease management might rely on severity scores that incorporate prognostic factors, bowel damage assessment and non-invasive close monitoring of disease activity to reduce the severity of complications

10.1039/D3FO00044C 65 HuangW.ZhuW.LinY.ChanF

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