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Overexpression of legumain in tumors is significant for invasion/metastasis and a candidate enzymatic target for prodrug therapy

Nat Protoc (2009) 4(1):316.10.1038/nprot.2008.214 41 KilkennyCBrowneWJCuthillICEmersonMAltmanDG

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In 2019, the multi-source analysis conducted by the CRPV [Centre Regional de Pharmacovigilance (French Regional Pharmacovigilence Centre)], which integrated complementary pharmacological data (clinical, pharmacoepidemiological, and experimental), confirmed and amplified the conclusions of the previous reports on the role of NSAIDs (in case of particularly ibuprofen, ketoprofen) in the aggravation of bacterial infections particularly in pulmonary infections 94

Consequently, membrane integrity is lost, producing a detergent-like effect, which eventually disintegrates the membrane by forming micelles, followed by bacterial cell death (Qiu et al., 2020

May also be taken after meals or before bedtime