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Knocking down PDIA4 significantly enhances sensitivity to chemotherapy drugs, suggesting it as a potential target for reversing drug resistance ( 5 Clinical applications and future prospects of disulfidptosis 5.1 Potential advantages over traditional biomarkers Biomarkers related to disulfidptosis, particularly SLC7A11, demonstrate unique advantages over traditional prostate-specific antigen (PSA) in the diagnosis of male urological cancers