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doi: 10.1111/jpi.12736 85 MadiganA

This function is analogous to that of ceruloplasmin in the circulation and brain: both HEPH and ceruloplasmin ensure that cellular iron release does not lead to toxic ferrous accumulation

Metabolic and melanocortin gene expression alterations in male offspring of obese mice

Importantly, this mechanism of paclitaxel activity was valid only at concentrations which inhibited angiogenesis without simultaneous induction of apoptosis [127]

Indeed, a study revealed that this compound attenuated the depressive-like behavior in stressed animals, mediating alteration in the hippocampal levels of anti-inflammatory and proinflammatory cytokines and inducing antioxidant actions, such as the modulation of SOD and CAT activities [86]

The positive effects of melatonin on cognition have also been documented in various human cohorts, including elderly subjects and patients with AD