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These tiny proteins, about one-tenth the size of regular antibodies, can access hidden spots on proteins that larger antibodies cannot access

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Reconstitution: Add 3.0 mL bacteriostatic water ~3.33 mg/mL concentration Typical Daily Dosage Range: 300800 mcg (gradual titration recommended) Measurement Guide: 1 unit 33.3 mcg (U-100 insulin syringe) Storage: Lyophilized: 20C (4F) Reconstituted: 28C (35.646.4F) Avoid freezethaw cycles Dosing & Reconstitution Guide Educational guide for reconstitution and daily dosing Standard / Gradual Approach (3 mL = ~3.33 mg/mL) Frequency: Once daily via subcutaneous injection

EAAT2-knockout mice exhibit fatal spontaneous epilepsy and increased sensitivity to acute cortical injury (Tanaka et al., 1997)

Considering the hydrophobic and highly lipophilic nature of cortisol molecules, tissue uptake most likely happens by passive diffusion

CC-3), DNA damage (-H2AX) and suppressing microtubule dynamic instability (Extended Data Fig