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Multiple reviews have highlighted ferroptosis as a promising target for various neurological disorders, and these reviews have also summarized the major regulators and associated studies in this field (178,200,201)

Hemolytic anemia and metabolic acidosis: think about glutathione synthetase deficiency

High oxidative stress states: Smoking, pollution, heavy alcohol use

Frataxin depletion does not cause overproduction of superoxides On the basis of the putative respiratory chain impairment and/or the iron-associated Fenton chemistry presumably resulting from iron mishandling, it has been inferred that frataxin depletion should result in overproduction of oxidant species

3) maintaining the essential thiol status of proteins

Ciriolo, Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy e-mail: [email protected] This article was submitted to Experimental Pharmacology and Drug Discovery, a section of the journal Frontiers in Pharmacology