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70 Bacterial metabolism has a significant impact on the effect of GSH on antibiotic susceptibility

METHOD DETAILS Drugs and small molecules Simvastatin (Selleckchem, S1792), pitavastatin (Selleckchem S1759), GCN2iB (MedChemExpress, HY-112654), and GSK2606414 PERK inhibitor (Millipore Sigma, 1337531-89-1) were dissolved in DMSO (Thermo Fisher Scientific, BP231), aliquoted, and stored at 80 C

Their therapeutic potential in EMs may be related to their ability to regulate mitochondrial quality control (MQC) and improve mitochondrial function

In preclinical studies, cancer cells were dependent on glutamine, and glutaminase inhibition led to reduced cell growth and induced apoptosis [8689]

65 , 219 , 220 The shared homology and cross-reactivity between gluten peptides and human epitopes reinforce the molecular mimicry pathway toward inflammation and end-organ dysfunction

ABBV-399 targets the SEMA domain of c-MET, blocking HGF binding and inducing receptor internalization, degradation, or cytotoxic effects [10]