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At late stages, it develops into geographic atrophy (GA), a chronic and progressive degeneration of retinal cells

The clearest signals are in eye disease using a drop formulation, such as neurotrophic keratopathy and dry eye [3] [4] , plus short-term infusion safety data in healthy volunteers [6]

Biochem Biophys Res Commun 112:5560 Lebo R, Kredich N (1978) Inactivation of human -glutamylcysteine synthetase by cystamine

Acute, regulated ROS generation is indispensable for effector activation, whereas chronic, unmitigated oxidative stress drives exhaustion of cytotoxic T cells while simultaneously reinforcing Treg-mediated immune suppression