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295,296 Non-nucleoside DNMT inhibitors are categorized based on their diverse mechanisms of action into competitors of S-adenosylmethionine (SAM), competitive or non-competitive inhibitors of DNMT, regulators of DNMT expression, and binders of DNA substrates

Overdose No cases of overdosage have been reported in the literature

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Based on the studies mentioned above, it is evident that copper overload can induce cell apoptosis through multiple molecular pathways, including the mitochondrial control pathway, endoplasmic reticulum stress-mediated pathway, and autophagy pathway

Feeding diabetes-prone BioBreeding (BBdp) rats a hydrolyzed casein-based diet, a diet that binds nutritional copper and lowers tissue copper, promotes islet cell neogenesis and results in 23-fold fewer diabetes cases compared with feeding cereal-based diets [ 43 ]

Am J Clin Nutr 78(3):361369