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Even though a significant change in the redox state occurs during normal aggregation

A recent study on autism found a link to two genetic mutations (not covered by 23andMe) in the gene that codes for the enzyme used to convert serotonin to melatonin

doi:10.1016/j.yexcr.2015.10.029

Diagnosis The diagnosis of PFIC is based on a combination of clinical data and laboratory or biochemical results, radiologic and histological evaluations if needed [13], with the crucial support of genetic testing [2]