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Life Sci 88(1112):535542 Ilic S, Drmic D, Zarkovic K et al (2011b) Ibuprofen hepatic encephalopathy, hepatomegaly, gastric lesion and gastric pentadecapeptide BPC 157 in rats

Starting at 0.25mg weekly for the first four weeks, then increasing to 0.5mg for weeks 5-8, then to 1mg for weeks 9-12, and continuing to step up through 1.7mg and 2.4mg at four-week intervals

doi: 10.1016/j.intimp.2022.109061 138

This section highlights key examples of TCM-derived metabolites that have made significant strides toward clinical translation, including berberine, quercetin, and the polyherbal Qili Qiangxin capsule, focusing on trial data, outcomes, and safety profiles ( 3.1 Clinical evidence and translational successes As a single-metabolite supplement, berberine has been used in East Asia for metabolic and cardiovascular health for decades, and Western interest has increased in recent years (Song et al., 2020)

Cells carrying the S allele exhibited higher levels of HO-1 mRNA, protein, and HO activity than cells carrying the L allele (Taha et al., 2010)

10.1002/path.4429 232 RevathideviS.MunirajanA