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Despite their benefits, weight gain, diabetes, metabolic syndrome, and cardiovascular disease are common side effects of this type of drugs, and insulin resistance that may be induced because of their use has been related to changes in DNA methylation, particularly with hypomethylation in fatty acyl CoA reductase 2 [246]

A sudden change could lead to unwanted health complications

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An Acad Bras Cienc 88:16551674 Brigelius-Floh R, Maiorino M (2013) Glutathione peroxidases