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Savona MR et al (2018) Phase Ib study of glasdegib, a hedgehog pathway inhibitor, in combination with standard chemotherapy in patients with AML or high-risk MDS

This occurs when cataracts begin to cause an aura around objects, and it happens most often during the daytime (Lasa 1995

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FIGURE 2 3.1 IRE1-XBP1 pathway Inositol-Requiring Enzyme 1 (IRE1) is an evolutionarily conserved ER stress sensor and an I-type transmembrane protein in the endoplasmic reticulum of all eukaryotes, including yeast and humans, playing a key role in maintaining endoplasmic reticulum homeostasis (Adams et al., 2019)