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doi: 10.1038/s41586-019-1405-y 88

The Glutathione-Superflow Resin selectively binds the GST-tagged protein under normal conditions, allowing the protein of interest to be separated from whole-cell extracts rapidly and efficiently

However, both glutathione and ascorbate react appreciably slower with singlet oxygen than tocopherols and, especially, carotenoids (Table 1)

To this regard, GSH may also have direct anti-SARS-CoV-2 potential: indeed a computational study indicates that the binding of spike protein to ACE2 is maximal when ACE2-sulfur groups are in the form of disulfides and impaired when fully reduced to thiols: hence a prooxidant environment with low levels of GSH would favor viruses cellular entry (Hati and Bhattacharyya, 2020)

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Energy deficiency also exacerbates eryptosis through specific signaling pathways