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Whitford W, Hawkins I, Glamuzina E, Wilson F, Marshall A, Ashton F, et al

Klasyczna hipoteza somatomedyny stwierdza, e GH wywiera swoje pierwotne dziaanie poprzez stymulacj wydzielania IGF-1 z wtroby, co nastpnie poredniczy w dziaaniu somatogennym w tkankach obwodowych, chocia wydaje si, e bezporednie dziaanie GH wystpuje niezalenie od zwikszenia poziomu IGF-1