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doi: 10.1016/s0031-9422(00)00235-1 17 HichriI.BarrieuF.BogsJ.KappelC.DelrotS.LauvergeatV

Amino acid composition and degradation vulnerability Not all peptides degrade at the same rate

When mitochondrial function is compromised, the efficiency of ATP production declines, leading to energy deficits in both cardiovascular and neural tissues

This post-translational modification is now recognised as a major mechanism of redox-regulated cell signalling, controlling the activity of transcription factors, kinases, phosphatases, and metabolic enzymes in response to the intracellular redox environment

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77 Additionally, AARS2 also mediates the lactylation of pyruvate dehydrogenase E1 component subunit alpha (PDHA1) at K336 and carnitine palmitoyltransferase 2 (CPT2) at K457/8, leading to the inactivation of both of these enzymes