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A key finding is that copper ions can directly induce the autophagic degradation of GPX4, thereby triggering ferroptosis [122]

Werner syndrome is the most common accelerated-aging syndrome derived from DNA repair defects, caused by the mutations of Werner syndrome ATP-dependent helicase ( WRN ), a gene coding for a protein implicated in telomere maintenance and homology-dependent recombination repair (Osorio et al., 2011)

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These results suggested that Re reduced blood pressure by activating the muscarinic or eNOS receptors, and blocking Ca 2+ channels (Dias et al., 2004)

Mazid et al., 2011)

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