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In women, its most relevant role may be during perimenopause and postmenopause, when both estrogen and MOTS-c levels decline simultaneously

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This is why slow titration produces fewer side effects at the same final dose

In the Billon 2023 paper, mice given 30 mg/kg IP still showed measurable plasma and muscle concentrations at 6 hours post-injection, which helps explain why twice-daily dosing was used in efficacy studies

Cardiac arrhythmias secondary to hypokalaemia during initial therapy have been reported

That said, BPC-157 is still a research chemical , not FDA-approved, and long-term human data is limited