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Immunoblot of indicated proteins in HeLa cells treated with Erastin (5 M) or indicated doses of RSL-3, an inhibitor of glutathione peroxidase 4 (GPX4) for 24 hours

Moreover, xCT is also expressed in the normal colon, but it was demonstrated that its overexpression in colorectal tumors is associated with the activation of MELK oncogene and Pi3K and RAS pathways, being xCT pharmacological blockade a way of affecting cancer cells tumorigenesis (111)

This protein stabilizes the fundamental components of translocation complexes when organized into oligomeric structures (41)

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2000 Apr;16(2):121-35

Sus funciones vitales incluyen: El glutatin es un potente antioxidante producido naturalmente por su cuerpo y se encuentra en alimentos como esprragos, aguacate y pepino