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Unmodified NPs are prone to aggregation, leading to liver/spleen accumulation and long-term toxicity, with 10 nm NPs causing liver damage in mice ( Single CeO 2 NPs lack responsiveness to the trauma microenvironment (e.g., pH, ROS), which leads to sudden drug release or premature inactivation (Zhao C

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In 1951 Conley and Krevans from the Johns Hopkins Hospital challenged the practice, raising the possibility that the neurological manifestations in some new pernicious anemia patients may be linked to previously prescribed high oral doses of folic acid (2028 mg/d) (12)

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