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Double-edged roles of ferroptosis in endometriosis Endometriosis is also an oestrogen-dependent gynaecological disease in which excessive oestrogen signalling transduction and altered oestrogen signalling pathways play an important role in its pathogenesis, resulting in oestrogen dominance and progesterone resistance [97, 98]

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Additionally, further exploration of the bidirectional communication within the axis particularly the impact of hypothalamic stress signaling on gut microbiota remains essential

Collectively, these findings suggest that disease-associated mutations, though mechanistically diverse, converge in their impact on astrocytic reactivity by resetting the threshold at which astrocytes enter reactive states

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