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In addition, GAMT activity was not detected in the head kidneys (a major immune organ) of HSB, and intestinal GAMT activity was high in 40-g HSB but was undetectable in 240-g HSB (Table 3) due to developmental changes in the tissue-specific expression of enzymes

Even when healing is achieved, recurrence rates approach 40% within 1 year, highlighting the urgent need for more effective therapeutic strategies that target the underlying molecular mechanisms

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