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However, as age increases, the balance between ROS production and antioxidant defenses deteriorates, leading to chronic oxidative stress across organ systems

Intensive Care Med (2020) 46(5):8468

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doi: 10.1016/j.bbrc.2018.12.039 109 KaganVEMaoGQuFAngeliJPDollSCroixCSet al

Notably, cells from patients with Zellweger syndrome, a PBD, show lysosomal cholesterol accumulation 26

doi: 10.3389/fphys.2018.00095 Received 25 October 2017 Accepted 29 January 2018 Published 14 February 2018 Volume 9 - 2018 Edited by Ali Mobasheri, University of Surrey, United Kingdom Reviewed by Felipe Simon, Universidad Andrs Bello, Chile