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Cephalalgia 14:184193 Lipton RB, Stewart WF (1998) Migraine headaches: epidemiology and comorbidity

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RCTs help to make study groups more similar and can provide a higher level of evidence, however they are subject to many biases66, and analysis of double-blind RCTs has identified extreme levels of bias67

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A patented standardized extract of concentrated polyphenols from French maritime pine bark, called Pycnogenol, has been shown to have broad anti-aging effects, and clinical trials indicate it may enhance cognitive function in healthy adults