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An alternative explanation may be that cystathionine was channeled towards glutathione synthesis to combat the oxidative stress that is induced by COC use 20

Boban-Blagaic A, Blagaic V, Romic Z, Jelovac N, Dodig G, Rucman R, et al

R., Vander Heiden, M

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Synthetic anticholinergics subsequently became the principal drugs to treat PD in the first half of the twentieth century and were joined by amantadine as a second non-dopaminergic agent in the late 1960s [131, 132]