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Since cholinergic components are express in many cells type and each of these cells is a possible target of OPs, both acute and chronic exposure to OPs may be related to the development of chronic neurodegenerative disorders, as well as allergies, or immunosuppression phenomena

Reyes JF, Ekmark-Lwen S, Perdiki M, Klingstedt T, Hoffmann A, Wiechec E, Nilsson P, Nilsson KPR, Alafuzoff I, Ingelsson M, Hallbeck M

Nikbaf-Shandiz, M

Oral ivermectin disposition is affected in horses by concomitant administration with antihistamines, including fexofenadine and cetirizine, which is in line with the well-known transporter-mediated interactions with systemic exposure (94, 95)