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ICH Q7 discusses primary and secondary reference standards and notes that secondary reference standards should be compared against a primary reference standard before first use [15]

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Intravenous injection of the fusion proteins resulted in partial tumor regression, while further studies demonstrated increased lymphocyte infiltration and the release of other proinflammatory cytokines within the tumor microenvironment, thereby strengthening the antitumor immune response

(Subramanian et al, 2005)] either using a customized gene set comprising enzymes involved in human glycolysis (henceforth, HUMAN-GLYCOLYSIS) or using the Reactome or Biocarta databases (Figure 1A

doi: 10.1111/jcmm.16581 29 ZhangHWangAShenGWangXLiuGYangFet al

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