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Carlota Oliveira Rangel-Yagui 1 , Adalberto Pessoa Junior, Leoberto Costa Tavares Department of Biochemical and Pharmaceutical Technology /FCF, University of So Paulo, So Paulo, Brazil Received 17 November 2004, Revised 2 February 2005, Accepted 4 March 2005, Published 8 July 2005 PDF Version Abstract PURPOSE : Micellar solubilization is a powerful alternative for dissolving hydrophobic drugs in aqueous environments

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Indeed, a recent clinical study reported significant differences in the variables of H 2 O 2 , OH, peroxidase, -tocopherol, total antioxidant capacity, matrix metalloproteinase-9, and tissue inhibitor of metalloproteinases-1 across treatment-resistant schizophrenia, chronically medicated schizophrenia patients, and healthy controls (195)

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Such findings reinforce that urate crystal deposition in tissues can be asymptomatic, but without appropriate management, the process can progress to destructive tophaceous disease ( Figure 1 - 10 ) over varying periods of several years to a decade or more

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