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A usability study is also being conducted with intended end-users of the POC G6PD test

But the additional GIP receptor binding domain makes tirzepatide a fundamentally different pharmacological tool

Upon bile acid activation, hepatic FXR induces expression of small heterodimer partner (SHP), which suppresses CYP7A1 and CYP8B1 gene transcription, thereby reducing bile acid synthesis ( FXR also participates in regulating glucose and lipid metabolism