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Like any weight-bearing joint though, when pain starts it can lead to considerable disability The main joints that can be affected with osteoarthritis (OA) are ankle joint sub-talar joint mid-tarsal joint big toe joint

Multivitamins with heavy metals (such as chromium, copper and zinc) or cold remedies (such as zinc lozenges) can cause a metallic taste

B12 patches I also found useless

A common question I get: why hasnt anyone done a proper large trial

The Structure and Function of Nervous Tissue, III: Biochemistry and Disease (Academic Press, New York, 1969)