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A completed phase III trial NCT02385188 found imiquimod together with paracetamol and lidocaine induced 82.6% response rate in vulvar Paget disease but 80% of patients needed painkiller to mitigate side effects (197)

Left untreated, hepatic steatosis advances to steatohepatitis, then to fibrosis, and eventually to cirrhosis

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however, this relationship has not been fully elucidated in honey bees 15,16

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Bonilla, M., Denicola, A., Marino, S.M., Gladyshev, V.N