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Symptoms of overmethylation can include: [23] Restless legs/pacing Hyperactivity High pain tolerance Histamine intolerance Sleep disorders Panic disorders Paranoia Insomnia Low libido ADHD Low motivation Depression Anxiety High levels of neurotransmitters (dopamine, norepinephrine, and serotonin) A high copper to zinc ratio Generally, undermethylation will result in symptoms more akin to depression and sluggishness, while overmethylation is usually linked to symptoms like hyperactivity and anxiety

Curcumin is being tested for use as an alternative anti-CCA agent 10,11

doi: 10.3892/mmr.1.2.239 76 ImranMSalehiBSharifi-RadJAslam GondalTSaeedFImranAet al

Belly Aches Join In Occasionally, Gilbert's likes to provoke disturbances in the belly region, which patients may view as a concern

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Pelttari, K., Wixmerten, A