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A clinical trial of the ASO tofersen in 50 patients with SOD1-ALS showed evidence of target engagement

Additionally, the pharmacist counsels the patient before medication administration and reports administration details to the patients prescriber

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Its functional loss will lead to extracellular glutamate imbalance and activation of extrasynaptic glutamate receptors, increase neuronal excitability, and cause epilepsy (12, 13)