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Additionally, the administration of BH4 rescued memory impairment in 13-month-old 3Tg-AD mice, without having any impact on the neuropathology [151], suggesting that the memory deficit may be linked to BH4 metabolism

Therefore, targeting the PGE2-EP2/EP4 axis or using antioxidants to protect TILs from ferroptosis can effectively restore the IL-2 sensitivity and metabolic health of TILs, thereby rescuing and expanding T cells with high anti-tumor activity and enhancing the efficacy of cell therapy and cancer immunotherapy

A deficiency can cause Hyperpigmentation, Skin dryness and Inflammatory skin conditions

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