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Targeted experimental validation was performed in murine myotubes/muscle tissue from mALD for mitochondrial oxidative function using high sensitivity respirofluorometry, structural evaluation of mitochondrial morphology using confocal microscopy, cristae morphology on 3D electron microscopy, HIF1a, and myostatin expression by immunoblots

For instance, curcumin analogs promote androgen receptor (AR) ubiquitination, disrupting GPX4-mediated redox homeostasis and inhibiting temozolomide-resistant glioblastoma growth [91]

However, translating this potential into effective therapies requires a much deeper understanding of ferritin biology

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Lancet (2018) 391:117485

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