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Supplementary Figure 4 GO assignment of identified DEGs in comparisons

An oxidative stress with free radicals is then induced, thereby increasing cellular death.5 Finally, a high level of ammonia in the brain may affect the autoregulation and cause hyperemia.6 Untreated, hyperammonemia can induce irreversible damage to a developing brain leading to uncontrolled seizures, motor and cognitive impairment, cerebral palsy, and/or death

Gastrointestinal protection BPC 157 was originally isolated from gastric juice and has a protective effect on the gastrointestinal tract

The peptide also prevents bacteria and toxins from entering and damaging the gut

Patients with PFIC3 might not show symptoms until 23 years old, unlike those with PFIC1 and PFIC2 [1, 2, 42, 44]